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How to log AppDomain start/shutdown in ASP.NET 2.0 in web.config
In this blog entry, you will find how to enable HealthMonitoring for Application Lifetime related events into your Event Viewer. You may want to do it if you want to know how often your ASP.NET 2.0 Application gets loaded/unloaded etc. Also, it could be a good point to verify if your AppDomain gets restarted for some reason (in the event logs you will see the reasons as well!!!) and eventually your session data gets lost sporadically.